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They work well but differ in how they might suit patients

Human studies have shown that PYY delays gastric emptying and promotes satiety (165), while short-term intravenous administration of PYY3-36 , at doses generating physiologic postprandial blood excursions, was shown to decrease calorie intake by approximately 30% in lean and obese subjects, without causing nausea, affecting food palatability, or altering fluid intake, nor was it followed by compensatory hyperphagia (166)

It helps maintain mitochondrial membrane potential and prevent the release of pro-apoptotic factors from mitochondria, thereby preserving cell viability (Pang, 2015)

Timing and frequency considerations Half-life and clearance: Determines dosing frequency

Usually temporary effect normalizing after 1-2 weeks