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Neurogenic inflammation in acute migraine attacks is characterized by a TVS activation-induced release of neuropeptides, such as CGRP and substance P, from trigeminal nerve fibers at the dura, which causes increased vascular permeability, plasma protein extravasation, leukocyte infiltration, vasodilation, mast cell degranulation, activation of meningeal nociceptors, and the subsequent release of inflammatory mediators (5)

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The chronic exposure of TM cells to oxidative stress leads to reduced cell viability and increased cell senescence [395] via the upregulation of cyclin-dependent kinase inhibitors p16 and p21 [396]

Adequate sleep: Good quality sleep supports overall health, including antioxidant levels

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