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The initial reaction in this chain is the conversion of citrate (an exporter of mitochondrial acetyl-CoA) to acetyl-CoA by ATP-citrate lyase

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Excessive PKC activity deranges the cell cycle, triggering abnormal angiogenesis in certain tissue beds (e.g., the diabetic retina or glomerular microvasculature) or augmenting apoptosis in other circumstances (e.g., in the aftermath of ischemia-reperfusion)