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However, numerous trials, especially in Phase II and III, have failed to achieve their primary endpoints (Liu et al., 2022a
doi: 10.1089/ars.2022.0214
Ultimately, randomized multicenter trials with extended follow-up will be required to confirm these findings and establish the long-term safety and efficacy of HA + GSH-C4 in G-OSD
The challenge with many interventions is that they lack selectivity, affecting multiple physiological systems simultaneously and creating side effects that limit their practical application or raise safety concerns
