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Superoxide levels were higher in noncontrollers compared with controllers and HCs (Figure 3F)

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Conversely, inflammatory phyla were notably expanded: Pseudomonadota (Proteobacteria) showed extreme enrichment, suggesting gut inflammation and barrier disruption, while Campylobacterota was significantly increased, consistent with pathobiont overgrowth

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Given that hepatotoxicants deplete glutathione (GSH) through a mechanism catalyzed by glutathione S-transferase (GST), it is reasonable to infer that these chemicals will enhance the activity of GST

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Sarker SA, McCallin S, Barretto C, et al

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