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B12 is essential for the methylation reactions required to produce the lipids and proteins that constitute myelin

when the intracellular Fe2+ overload exceeds the caching capacity of ferritin, and intracellular free iron generates ROS through the fenton reaction, and glutathione (GSH), one of the critically important antioxidants in cells, is catalyzed by peroxidase to oxidized glutathione (GSSG) during lipid peroxidation, and inhibit lipid peroxidation-induced ferroptosis (119)

This enzyme conjugates 17estradiol and other estrogens in a step leading to their inactivation

doi: 10.3390/antiox8090392, 53

That means that the earliest phase in theory will have the least amount of information regarding safety and effectiveness
