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Even so, moving from this biochemical function to clinical outcomes is not always straightforward: the evidence can be heterogeneous and depends on dose, duration, the population studied and lifestyle variables

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Koves, T

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Morphological and developmental alterations have been observed in the M1 of SMA murine models, including a selective degeneration of layer 5 pyramidal neurons and differences in intrinsic synaptic and neuronal properties, from pre-symptomatic to late symptomatic disease stages [10, 18, 19]