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These studies have established MT-II as a research tool for studying how melanocortin receptor activation engages the oxytocinergic system as a downstream effector pathway
To support transparent clinical reasoning, the certainty of evidence for each action has been indicated in the figure using GRADE-based labels

doi: 10.1016/0014-5793(74)80667-8

They are often one of the reasons it succeeds or fails
