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Description
None of the identified therapeutic compounds have been specifically tested in periodontal models, and future studies should include systematic ADMET predictions, in vitro cytotoxicity assessments, and preclinical validation before clinical translation

ClinicalTrials.gov (2020)

Curr Genet 23:408413

Key findings from Table 2 include the following: dietary fiber (NSPs/RS) and Omega-3 (EPA/DHA) exhibit strong or high evidence levels, supported by consistent, low-bias human RCT

241,242 However, the study did not observe an increase in Bacteroidetes and a reduction in Firmicutes, as reported in both R6/1 and R6/2 mice
