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The sulfenic acid intermediate formed at the catalytic cysteine readily reacts in 2-Cys Prxs with the resolving cysteine to release water under the formation of a disulfide bond (Fig

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However, a recent large global, multicenter phase II study of HCC showed that ADI-PRG-20 combined with 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) was associated with an ORR of 9.3% versus 8.15% with FOLFOX4