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Supplementing BH4 can reverse DHFR inhibition-induced ferroptosis in GCH1 knockout cells [82, 83]

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10.3892/ol.2022.13224 268 ZhangQ.YiH.YaoH.LuL.HeG.WuM.et al (2021)

The most striking example of this is the dramatic difference seen between the clinical stages of tumours with a Gleason score of 7, depending on whether there was a primary pattern of 3 and a secondary pattern of 4, and vice versa (3 + 4 = 7, and 4 + 3 = 7, respectively)

Instead, it focuses on what can be reasonably discussed from a research standpoint: molecular identity, reagent quality, cell migration assays, endothelial tube-formation models, VEGFR2-axis-associated readouts, nitric oxide-associated hypotheses, and the limitations of current mechanistic evidence