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Within the same observation, over half of the patients studied had medication coverage for fewer than 20% of the days of the year, and only 9.3% exhibited a very high level of adherence [35]

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If patients experience new or worsening symptoms of hypothyroidismsuch as increased fatigue, cold intolerance, constipation, dry skin, or unexplained weight gain despite tirzepatide therapythyroid function testing may be needed to assess whether levothyroxine dose adjustment is required