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Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different

Indeed, the interpretation of TSPO binding is complex, with the authors of a recent review stating: At present, it is not clear whether the presence of TSPO PET signal indicates a predominantly pro-inflammatory or anti-inflammatory state, nor whether the signal indicates the presence of destructive or reparative cell states. [73]

The vascular effects of cocaine include angiogenesis and vasoconstriction, in contrast to heroins predisposition to ischemic and hemorrhagic complications

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