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One unique feature of the HGA/MVA pathway is that shikimate (via tyrosine) ultimately provides the quinone moiety of the 1,4-naphthalenoid ring, compared with the OSB and 4HBA/MVA pathways in which shikimate (via isochorismate and phenylalanine, respectively) provides the benzene moiety (Figure 2)

They are considered to be drugs that can effectively target glutamine metabolism and show great anticancer effects [34, 53]

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Oxidative stress leads to neuronal inflammation and is part of the therapeutic goal in all neuroprotective treatments because it causes apoptosis (2, 3, 8, 9)

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