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The controlled conditions of clinical research also differ from real-world use
Not all hormones undergo marked fluctuations during the normal menstrual cycle
Impaired immune function, peripheral neuropathy, glossitis (swollen tongue), and skin conditions

From a compliance perspective, the key requirement is separate medical necessity and distinct documentation
Hillefors M, Gioio AE, Mameza MG, Kaplan BB (2007) Axon viability and mitochondrial function are dependent on local protein synthesis in sympathetic neurons
