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Tumour cells that undergo rapid proliferation have a high requirement for DNA synthesis and are prone to overexpression folate receptors [203,204]

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CprRS regulates a narrow set of approximately 15 genes, including arnBCADTEF and pmrAB , whereas ParRS controls a broader transcriptional response [69]

(2021) showed that melatonin induces the upregulation of Sirtuins3 (SIRT3), which in turn modulates the AMPK/mTOR pathway and enhances autophagy, thereby mitigating small intestine damage in sepsis

Beyond classical antioxidant signaling, GSH interfaces with additional pathways, including Hippo-Yes1 associated transcriptional regulator (YAP1) signaling to regulate GPX4 and SLC7A11 expression, 159,160 mechanistic target of rapamycin kinase (mTOR) signaling to influence GPX4 protein synthesis through cysteine metabolism, 161 and NF-B signaling to restrain inflammation-associated ROS production 162