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Theoretically, deficiencies in GPx3 and cystine reduce the ability of the body to counter oxidative stress by virtue of the glutathione pathway and associated enzymes, which may lead to increased ROS in the circulation

Abstract Background Solute carrier family 38 member 5 (SLC38A5) is an amino acid transporter that plays a significant role in various cellular biological processes and may be involved in regulating the progression of tumors However, its function and underlying mechanism in osteosarcoma remain unexplored

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