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The mammalian sirtuins (Sirt1--Sirt7) participate in a number of cellular and physiological functions such as gene silencing, apoptosis, mitochondrial function, energy homeostasis, and longevity [237].Transgenic mice with overexpression of the sirt1 gene demonstrate decreased lipid-induced inflammation, improved glucose tolerance, and protection from hepatic steatosis when fed a high-fat diet [238]

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Nevertheless, 14 samples declared as containing only AAS and other substances contained undeclared PCT medicines, including tamoxifen (n = 5), clomiphene (n = 5), raloxifene (n = 3), and exemestane (n = 1) (Table 2)