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Description

C domains are most commonly encoded in the same coding DNA sequence (CDS) as their acceptor molecules, upstream of the corresponding A domain and there are only very few examples were a C domain is located in the C terminal proximitiy of the preceding CDS in NRPS 32,33,34

Data collection carried out in the Brigham and Women's Hospital Center for Clinical Investigation (formally supported by NIH Grant M01 RR02635 currently part of Harvard Clinical and Translational Science Center supported by NIH UL1 RR025758)

Interestingly, the mRNA levels of F10 showed elevated expression (Fig

Therefore, bi-directional causal effects were observed, and instances of true bi-directional pathway might exist, and in other words, a proposed positive effect of vitamin B12 on NAFLD risk, whereas NAFLD also exerts a positive effect on vitamin B12, possibly as part of a positive feedback loop