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First principles for therapy design Therapy design should follow three first principles: target the source before the sink, prioritizing isoform- or site-specific modulation of NOX enzymes, mitochondrial ROS sites, ER oxidoreductases, or iron handling rather than indiscriminate scavenging that can blunt physiological signalling (Sies et al
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Think of it like going to the gym - consistency matters more than intensity

Fakhar-e-Alam: Conceptualization, Investigation, Validation, Supervision, Project administration, Writing review & editing

hCiPSC treatment attenuated these changes, reducing Clostridiales and Desulfovibrionales while elevating Verrucomicrobiales and partially restoring Bacteroidales
