nadph and glutathione protect cells against reactive oxygen derivatives Overview of Cellular Oxidative Stress Pathways Antioxidant Defense Pathways of reactive oxygen species
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2.5.3 Saponins 2.5.3.1 Tubeimoside-1, ginsenoside Rk3, polyphyllin VI, aescin, sasanquasaponin , ginsenoside Rg5 and platycodin D Saponins exert their anticancer effects mainly by suppressing cell proliferation and migration, inducing autophagy and promoting cancer cell apoptosis

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349 Meanwhile, RA patients typically have lower antioxidants, such as GSH and GSH peroxidase, and treatment with methotrexate significantly changes oxidative stress indicators in RA patients

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These same principles could be extended to the design of inhaled peptide and protein therapies aimed at navigating or modulating the mucus barrier, particularly by integrating aerodynamic design with mucus-penetrating or mucus-protective features
