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Description
Klein et al., 2023[60]

Additionally, the patients were asked to complete supplementary assessments mid-treatment (week 4) and at the end of treatment (week 8) to evaluate their subjective experiences with the assigned treatments

Side Effects & Safety Current knowledge of Dihexa's safety profile is primarily based on animal studies, with no formal human safety data available

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It was demonstrated that in the spinal cord of the SOD1-G93A ALS mouse model, the mitochondrial receptor SQSTM1/p62 is recruited to the mitochondrial surface, where it activates mitophagy, whereas knockdown of the Parkin gene reduces the loss of motor neurons, thereby delaying the progression of disease in SOD1-G93A mice (Palomo et al., 2018)
