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We generated a PRISMA diagram to describe the flow of information through the processes of identification, screening, and including records in this literature review, as shown in Figure 1 [23,24]

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Potential advantages and limitations from a clinical pharmacokinetic perspective

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preferably wherein the separating is conducted before step c)

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Evening before bed is the dominant protocol because it amplifies the natural nocturnal GH surge (which peaks ~90 minutes into deep sleep)

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