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The Wnt/-catenin-transcription factor 4 (TCF4) axis further reinforced cuproptosis resistance through transcriptional induction of the copper exporter ATP7B, which was validated through chromatin profiling and functional assays

The researchers mixed AOD9604 with human blood serum and rat plasma in test tubes to simulate what happens after the peptide enters the body

All patients were randomly divided into three groups by drawing lots and received three different medication treatments for 12 weeks

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In laboratory settings, FOXO4-DRI is used as a research reagent for experimental systems examining FOXO4-p53 protein interaction disruption, senescent cell modeling, DNA damage signaling assays, and oxidative stress research