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(A) Exemplar images of DAPI and SRB co-staining in control (CON), PRO (4.7 mM) and PE

At the phylum level, the relative abundance of Proteobacteria and Chloroflexi was increased in ITP patients, while Firmicutes , Actinobacteria and the Firmicutes/Bacteroidetes ratio were decreased

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Importantly, such dual-site immune cell infiltration has not been confirmed in human studies and should therefore be interpreted as preclinical evidence

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