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NDD is defined as progressive age-associated deterioration of neural function, primarily driven by neuronal loss

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The metaeffector AnkJ inhibits the activity of Ceg14 by direct protein-protein interaction A systematic analysis using yeast genetics suggests that AnkJ is a metaeffector of Ceg14 which functions to modulate its activity 55

This gives rise to a learned helplessness, reinforced by reliance on long-term, expensive and potentially harmful immunosuppressive medications, creating a feedback loop

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