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SPEVIGO is a humanized antagonistic monoclonal immunoglobulin G1 antibody blocking human IL36R signaling currently under investigation for the treatment of flares in adult patients with generalized pustular psoriasis (GPP)

doi: 10.1002/jcb.23449

NRF2 system Nuclear factor erythroid 2-related factor2 (NRF2), a stress-induced transcription factor that is essential to maintain redox homeostasis

24 There have been reports that phenolics also inhibit the expression of both HMG-CoA reductase, involved in the regulation of cholesterol biosynthesis, and sterol regulatory element-binding protein-2, which triggers HMG-CoA for cholesterol biosynthesis in the liver

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