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Additionally, glycation also interferes with the growing end of -synuclein fibrillation but does not affect the nucleation step ( 2.7 Effect of metal ions and their salts on fibrillation Brain regions affected by neurodegenerative diseases such as PD, Alzheimers disease (AD), Amyotrophic Lateral Sclerosis (ALS) and Mass Spectrometry (MS) are found to contain significantly higher concentrations of metal ions such as zinc, iron and copper (Miller et al., 2006)

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Moreover, CBD inhibits AEA uptake by acting on a putative endocannabinoid membrane transporter (EMT) [9,16] and/or competition with AEA for binding to fatty acid binding proteins (FABP-3, -5, -7), which constitute an intracellular endocannabinoid transport system [10]

Although several predictors and predictor tools have been developed, they need to be validated/recalibrated to the local population before they can be used

Wu L, et al