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TrkB Agonists: Directly Enhancing Neurotrophic Signaling If your goal is to directly and specifically augment deficits caused by BDNF, TrkB agonists present the most appropriate means of activating TrkB, the receptor that mediates neurotrophic signaling and ultimately leads to synaptic plasticity

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Acknowledgments Parts of the figures were generated using Servier Medical Art, provided by Servier ( licensed under CC BY 4.0 ( and NIH BIOART Source ( Author Contributions Conceptualization, M.J

doi: 10.1371/journal.pbio.3001480 195 MaekawaTSasaokaTAzumaSIchikawaTMelroseHLFarrerMJet al

Chakravarthy 2010)