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(2) Risks to subjects are reasonable in relation to anticipated benefits, if any, to subjects, and the importance of the knowledge that may be expected to result

Neither cyanoB-12 nor methylB-12 have the properties of hydroxyB-12 as far as detoxification and redox control and cyanoB-12 cannot be used at high dose as it carries cyanide

This pattern is more consistent with a medium-level resistance mechanism mediated by factors such as efflux pump activation or modification of the target lipopolysaccharide in the bacterial outer membrane

September 6, 2009

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