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Lancet 380, 499505

The first destroys free radical superoxide converting it in H 2 O 2 which is then reduced by catalase 72

Figure 5 4.4 Direct TAM cancer cell ferroptosis interactions: a mechanistic narrative Tumor-associated macrophages (TAMs) orchestrate ferroptotic sensitivity in cancer cells through a set of tightly interlinked metabolic and immunological interactions (74)

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Also, some concerns about sarcopenia exist, although more definitive data are still missing 26