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DOI: 10.48550/arXiv.1810.00826 23
Such split is susceptible to clustering in chemical space, and therefore can result in structurally similar pesticides in both training and testing sets 20,46
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Before any scientific compound can be considered safe and effective for clinical use, it typically requires multiple phases of well-designed human clinical trials that evaluate dosage, safety, efficacy, long-term outcomes, and reproducibility
