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Beta-thalassemia in Mediterranean countries

The process of ferroptosis, mediated by iron overload-induced ROS accumulation, has been shown to drive macrophage polarization towards the M1 phenotype through the ROS/acetyl-p53 pathway, thereby enhancing CD8 + T cell infiltration in the TME [119, 120]

The timeline may vary depending on individual responses.

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Ceramide-induced activation of NADPH oxidase and endothelial dysfunction in small coronary arteries
