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In commonly used HFD/STZ-induced type 2 diabetes animal models, our study discovered that MELNs significantly attenuated T2DM progression

The specific genera that increased in the PSO rats were Lachnospiraceae_NK4A136_group , Bacteroides , Clostridia_vadinBB60 , and Roseburia , while Alloprevotella , Muribaculaceae , and Alistipes , Prevotellaceae_UCG-001 , Rikenellaceae_RC9_gut , and Clostridia_UCG-014 decreased significantly ( Figure 3F )

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