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Both enzymes, GPX7 and GPX8, are located in the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins, and GPX8 also plays an important role in the regulation of Ca 2+ in the endoplasmic reticulum

Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency

Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II

However, their therapeutic outcomes are limited because of drug resistance due to the intracellular inactivation effect (Johnstone et al., 2016)