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To tackle practical research challenges, highly specific sgRNA design tools and various suitable mutant Cas proteins have been developed, including nCas9 for constructing base editors

Yue Q, Wang Z, Shen Y, Lan Y, Zhong X, Luo X, et al

JungYWenTMinglerMKCaldwellJMWangYHChaplinDDet alIL-1 in eosinophil-mediated small intestinal homeostasis and pathogenesis of inflammatory bowel disease

An investigational therapy that is not FDA approved

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