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Thus, future studies should focus on identifying specific and stable metabolic biomarkers and developing multi-targeted therapeutic drugs (Fig

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doi: 10.1016/j.brainres.2011.12.028

Several other double-blind, randomized, placebo-controlled trials have confirmed the efficacy of disulfiram on cocaine intake (44, 45) , with a potentially greater effect in males (46) , but none have been designed to investigate the mechanisms of disulfiram-induced cocaine abstinence