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Because the symptoms of vitamin deficiencylike fatigue, brain fog, or tingling handscan be vague, the best approach is a two-step process

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Excessive ROS can activate MAPK, such as cJun Nterminal kinase (JNK), which phosphorylates specific serine/threonine sites on insulin receptor substrates (IRS) and inhibit their ability to interact with the insulin receptor [122]
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