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Metabolism of coenzyme Q10: biliary and urinary excretion study in guinea pigs

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They can assess whether the symptoms are genuinely related to the supplement, investigate alternative causes, and determine the most appropriate management strategy

Here, CoQ 10 is kept in equilibrium between its redox forms outside the mitochondria by the actions of three enzymes: nicotinamide adenine dinucleotide reduced/nicotinamide adenine dinucleotide phosphate (NADH/NADPH) reduced oxidoreductase, NADH cytochrome b 5 reductase, and NADPH-coenzyme Q reductase (Figure 1) [6,7,8]

USA 108 , 59545963 (2011)