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Regulation of tumor necrosis factor (TNF)-alpha synthesis and TNF receptors expression in T lymphocytes through the CD2 activation pathway

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Crystallographic studies have revealed that the nonnucleoside RT inhibitor binding pocket (NNIBP) includes solvent-exposed regions, such as tolerant regions I represented by the Pro236 hairpin loop, as well as tolerant regions II encompassing the entrance channel characterized by a large open region preceding Glu138 (Fig

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