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Further studies are warranted to evaluate the potential interactions of natural products with TAM in clinical settings

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These data suggest that the majority of LRRK2-mediated phosphorylation signal minimally resides within residues 252359 of ArfGAP1 (GAP-F5 fragment), although additional less abundant sites are likely to exist outside of this region as suggested by higher phosphorylation of the GAP-F1 fragment (residues 137415