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doi: 10.1080/15548627.2018.1532259 58 KettelPKaragzGE

Although the trend is consistent, the predicted PK curves did not align well with the observed data for the 2 mg and 40 mg dose groups

This direct bioactivity and immediate availability for methylation processes distinguishes the l-methionine vs sam-e therapeutic profiles dramatically, as SAM-e bypasses the rate-limiting enzymatic steps required for L-methionine conversion, enabling more rapid onset of therapeutic effects and more predictable clinical outcomes in applications requiring enhanced methylation support

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Be wary of these claims, however, since the effects on your skin may be far less than is seen in laboratory testing