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10.1038/s41575-020-0273-0

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These findings collectively demonstrate that EC metabolism involves a coordinated sequence of intestinal absorption, hepatic and colonic biotransformation, and renal elimination, with distinct phase II conjugates acting as clearance intermediates and serving as characteristic metabolic signatures of EC exposure (Figure 3)

Yumita A, Suganda AG, Sukandar EY (2013) Xanthine oxidase inhibitory activity of some Indonesian medicinal plants and active fraction of selected plants