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Importantly, decline in cellular NAD levels has emerged as a potential key player in the pathogenesis of several diseases including age-related conditions (Table 1) [1-32]

and thus, it could indicate that low circulating levels of IGF-1 can lead to MetS and raise the risk for CVD and T2D

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(2002) Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in haemodialysis patients receiving high-dose folic acid supplementation
