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It has been also recently demonstrated that dynamic changes in mitochondrial morphology are associated with high glucose-induced overproduction of ROS and inhibition of mitochondrial fission prevented periodic fluctuation of ROS production during high glucose exposure [141]

When we mutate the K3 D , K7 D and K314 D to alanines, both the rotation angle ( Z ) increases and the distribution of the distance to the binding site (d heme-H85 ) is broadened (Supplementary Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Johnson WT, Newman SM., Jr Hearts in adult offspring of copper-deficient dams exhibit decreased cytochrome c oxidase activity, increased mitochondrial hydrogen peroxide generation and enhanced formation of intracellular residual bodies

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