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Here is when D64.9 is appropriate: The patient presents with anemia symptoms, but lab results are pending The provider suspects anemia, but the diagnostic workup is not complete The patient was transferred from another facility with limited records Here is when D64.9 is not appropriate: Iron studies confirm iron deficiency use D50.9 instead B12 level confirms deficiency use D51.9 instead Patient has known chronic kidney disease use D63.8 instead Patient had a recent surgery with bleeding use D62 instead Switch from D64.9 to the specific code within one visit or one follow-up

Several situations warrant a conversation with your prescriber about adjusting your protocol

Assuming that the percentage of patients showing an increase in serum vitamin B12 concentration to above 179 pg/ml in both groups is 70%, means the study requires at least 304 patients (152 in each arm) for a threshold of non-inferiority of 10% and a statistical power of 60% with significance set at p 179 pg/ml: patient preference questionnaire Randomisation of patients to treatment group Visit 1 (start of treatment) Anamnesis: record whether the patient lives alone or with others, lifestyle habits, use of alcohol, whether a vegan diet is followed, whether the patient has undergone gastrectomy Symptoms: record paresthesia, asthenia, loss or reduction of appetite, sadness or change in state of mind, concomitant pharmacological treatment Physical examination: for Hunters glositis, positional and vibrational sensitivity Questionnaires: Lobo cognitive mini-exam, EuroQoL-5D Record concomitant treatment Request analyses to be performed one week before next visit: haemogram and serum vitamin B12 Therapeutic plan: patient in oral arm provision of medication

Also, there is a need to establish collaborative platforms between interdisciplinary teams, including basic researchers, clinicians, and industry partners, to take bench work to a product or treatment