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However, as common obesity is a state of leptin resistance, the exogenous administration of even exceedingly high doses of leptin has proven relatively ineffective at reducing body weight [14-16]

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Reference sources: Sigma-Aldrich 5-Amino-1MQ (SML2832) | NIH PMC NNMT Inhibitor Research Regulatory Notice 5-Amino-1MQ is an unapproved new drug compound

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