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Their incidence is increasing globally, currently accounting for ~15% of all primary liver cancers and ~3% of gastrointestinal malignancies

Yellon SM, Foster DL

GIP has been shown to decrease food intake while blunting the metabolic adaptive responses that usually occur with calorie restriction resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids

Indeed, MC4R antagonists reduce immobility in the forced swim test and increase exploration in the elevated plus maze, indicating both antidepressant and anxiolytic effects [50, 51]