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Cholinergic neuronal loss is closely associated with excessive permeabilization of the mitochondrial membrane, opening of the mitochondrial permeability transition pore (mPTP), and subsequent release of pro-apoptotic factors such as cytochrome c

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-Tocopherol and -carotene supplements and lung cancer incidence in the -Tocopherol, -Carotene Cancer Prevention study: effects of base-line characteristics and study compliance