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At the end of the administration, we sacrificed the rats by intraperitoneal injection of 3% pentobarbital sodium (100 mg/kg), and the tissue samples were processed differently according to the different experimental protocols

The N-myristoylation of FSP1 is crucial for its specific localization to the plasma membrane, facilitating its role in ferroptosis suppression

Mechanism of Action GLP-1 agonists exert their effects through multiple mechanisms, all of which contribute to their therapeutic benefits

Cell proliferation induced by GPE was further delineated by an increased level of phosphorylated Akt, indicating potential upregulation of the ERK ( Figure 6 ) and PI3K/Akt signaling pathways ( Figure 7 ) pathways, which are among the signaling pathways involved in the regulation of cell proliferation

There is also increasing evidence that deregulation of GSH synthesis contributes to the pathogenesis of diseases such as diabetes mellitus, pulmonary and hepatic fibrosis, alcoholic liver disease, cholestatic liver injury, endotoxemia, and drug-resistant tumors cells [10]